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Sernova, Diabetes and Haemophilia

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Published : July 26th, 2016
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Paul Lacey was a researcher at Washington University when, in 1972, he cured some diabetic rats by transplanting the islet cells from healthy rats into diabetic ones.

Over the next two decades researchers made many attempts to apply the procedure to humans. Unfortunately no one was successful. By the early 1990’s most scientists had come to the conclusion that islet-cell transplantation was a lost cause.

Drs. James Shapiro, Jonathan Lakey and colleagues from the University of Alberta in Edmonton were successful at improving the treatment of a select group with severe diabetes through development of the Edmonton protocol in the late 1990s.

The Edmonton Protocol is a method of transplantation of pancreatic islets into the portal vein of the recipient's pancreas. These pancreatic islets are sourced/extracted from pancreases removed from recently deceased adults.

Each recipient receives islets from one to three donors. The islets are infused into the patient's portal vein, and are then protected from the recipient's immune system through the use of two immunosuppressant drugs as well as an antibody drug specifically used in transplant patients.

Since 2000 close to a thousand people have received islet transplants – but by five years after the procedure, on average fewer than 10% of all patients are free of daily insulin supplementation. Thus, while islet cell transplantation has demonstrated exciting success and the potential for cell therapy as a treatment for diabetes has great promise, further technology developments are required.

Exactly what is Diabetes?

Diabetes is a condition in which the sugar levels in the blood are too high on a constant basis. Without tight blood sugar control to normal levels, this can result in severe long term medical consequences.

Much of the food one eats is broken down into a simple sugar called glucose. In response to a rise in glucose levels after a meal the islet’s beta-cells in the pancreas detect blood glucose levels and secrete insulin into the blood. Insulin acts to open the gates of cells allowing the glucose to move from the blood stream into the cells where it can be utilized for energy.

A Type 1 diabetes diagnosis means the pancreatic beta cells that read glucose levels and secrete insulin have been damaged or destroyed. Thus, glucose cannot move from the bloodstream into the cells allowing blood sugars to rise.

A Type 2 (insulin resistance) diabetes diagnosis is a far more common verdict for people than Type 1. Insulin resistance occurs as a result of chronically elevated blood sugar and insulin levels. These elevated levels of sugar and insulin have the effect of "numbing" the cellular processes which move the sugar from the blood stream to the cells - the body cannot respond to the insulin "requests" to move blood sugar into the cells. Approximately 27% of the people who start out as Type 2 diabetics, will, in the future require insulin injections similar to Type 1 diabetics.

Diabetic complications, which occur even in individuals taking insulin injections, include irreversible damage to the heart, blood vessels, eyes, kidneys, skin, feet and hearing. In individuals taking insulin injections to reduce blood sugar levels, severe hypoglycemia from a single injection of too much insulin, can cause organ failure, coma and death.

Diabetes is not considered a high mortality condition, but it is a major risk factor for other causes of death and has an extremely high attributable burden of disability, for example; 2% of people with diabetes become blind, about 10% develop severe visual impairment, and 50% of people with diabetes die of cardiovascular disease.

Standard of Care

The Standard of Care for patients with reduced or missing critical hormones or proteins, such as insulin, is often monitoring and injecting these proteins multiple times a day.

A search has been on for an alternative site for islet transplantation as well as for an optimal medical device in which to implant the islets (therapeutic cells). Several subcutaneous devices have previously been developed for islet transplantation but from a preclinical and clinical perspective the results from these products have been generally disappointing.

Current cell therapy is limited to poor cell survival, inappropriate delivery of hormones and a lack of available donors and cells. At this time there is no approved device to house and protect therapeutic cells in the body.

Sernova Corp. (TSX-V: SVA) (OTCQB: SEOVF) (FSE: PSH)

Sernova Corp is a Phase I/II clinical stage company developing medical technologies for the treatment of chronic debilitating metabolic diseases to replace proteins or hormones in short supply within the body.

The first proprietary platform technology is the Cell Pouch System™. Think of SVA’s Cell Pouch System™ as a potential natural insulin producing pump with the added benefit of fine-tuned glucose control with no need to replenish the insulin. When placed under the skin and filled with islets it can develop pancreas-like characteristics taking over normal blood glucose control. The device uniquely forms highly vascularized tissue chambers for the placement, survival and function of therapeutic cells. Insulin producing islets transplanted in the device have been proven to become connected to microvessels and able to produce all of the regulatory hormones to control diabetes.

Sernova is exploring the additional utility of the Cell Pouch System™ as an enabling platform for a range of therapeutic cell types and diseases. The technology could be used for a patient’s own cells (autograft), or a donor’s cells (allograft).

The therapeutic cells placed into the device may also be cells that can be a source to treat millions of patients such as stem cell derived therapeutic cells (stem cells have the ability to differentiate into other cell/tissue types) or xenogeneic (derived or obtained from an organism of a different species) cells.

Sernova’s products are also designed to allow for multiple market expansion opportunities within each therapeutic area. For example, the technology would be beneficial if it provided a simple reduction in the number of daily therapeutic injections a patient must take; however, there is the possibility that it could even essentially ‘cure’ the disease through natural release and regulation of the therapeutic proteins or hormones.

Sernova’s trials

Sernova’s products are uniquely focused on those diseases in which a protein, hormone or factor, missing or in short supply in the body, could be replaced by therapeutic cells which release those factors into the bloodstream.

Diabetes and hemophilia are but two of the multibillion dollar market opportunities where such treatments could lead to:

  • A significant improvement in the quality of patient’s lives
  • Reducing health care costs
  • Potentially reduce the devastating side effects of disease

While other scientific laboratories around the world were advancing stem cell technologies which, if successful, would provide sources of therapeutic cells for various clinical applications, Sernova was in parallel working on their proprietary, scalable, implantable medical device (Cell Pouch System™) that creates a natural environment for the survival and function of these therapeutic cells.

Sernova is in the forefront of such technologies. 


Richard (Rick) Mills
Ahead of the Herd


About 347 million people worldwide have diabetes. The World Health Organization (WHO) projects that diabetes will be the 7th leading cause of death in 2030.

July 12, 2016 – Sernova Corp. a clinical stage company developing disruptive regenerative medicine technologies for the long-term treatment of chronic diseases including diabetes and hemophilia, is pleased to announce today it has entered into a research funding agreement with JDRF, the leading global organization funding and advocating for type 1 diabetes (T1D) research.

The purpose of the funding is to advance human clinical trials of Sernova’s Cell Pouch System(TM) (CPS)technologies for treatment of hypoglycemia unawareness patients with severe type 1 diabetes. T1D is a life-threatening disease in which the body's immune system mistakenly attacks and kills the pancreatic cells that produce insulin—a hormone that is essential for life because of its role to help the body use glucose.

JDRF will provide Sernova up to US$2.45 million to support a clinical trial at a major transplantation center in the United States. The goal of the study is to provide patients with hypoglycemia unawareness a novel cell therapy treatment utilizing Sernova’s proprietary, highly vascularized, cell macroencapsulated implantable and scalable device to reduce or eliminate the need for injections of exogenous insulin.

“Sernova’s progression to human clinical trials is an incredible accomplishment in the global diabetes research agenda. I am particularly proud of this trial being a part of the JDRF portfolio because it supports advancements of the best and brightest research minds in Canada at Sernova. Also, this is a shining example of the international collaboration fostered by projects funded by JDRF. Working together with our global partners, we can accelerate this type of transformative research and ensure it becomes available for the T1D community.” Dave Prowten, President and CEO of JDRF Canada.


Patients with hemophilia A have a defective gene for factor VIII. Patients receive prophylaxis factor replacement therapy two to three times a week. Prophylactic therapy (prevention therapy) involves three infusions of Factor VIII each week at a hospital at a cost of about USD$200,000/yr.

December 21, 2015 – Sernova Corp. announced today that the European Commission’s Horizon 2020 program has awarded a Euro 5.6M ($8.5M CAD) grant to a consortium consisting of Sernova Corp and five European academic and private partners to advance development of a GMP clinical grade Factor VIII releasing therapeutic cell product in combination with Sernova’s Cell Pouch(TM) for the treatment of severe hemophilia A

February 16, 2016 – Sernova Corp. announced today it has received its initial € 566,500 ($875,000 CDN) installment of non-dilutive funds from the HemAcure Grant funded by the EU Horizon 2020 Program. Sernova will use the payment to fund activities related to the development of a GMP clinical grade Factor VIII releasing therapeutic cell product combined with Sernova’s Cell Pouch(TM) to treat severe hemophilia A, a serious genetic bleeding disorder caused by missing or defective factor VIII in the blood stream.

“We are excited that the HemAcure consortium partners, a group developing a therapeutic that is highly disruptive to the current standard of care treatments for hemophilia A, are already working diligently to advance the program. Together, we are working to address, with a sense of urgency, the critical challenges posed by severe hemophilia A.”  Dr. Philip Toleikis, Sernova President and CEO.


Since late December 2015, Sernova and its collaborative partners have announced funding of joint research hemophilia and diabetes collaborations totaling Cdn$11,780,000.00.

Individually each of these collaborations is massive validation of Sernova’s technology. Taken together they show a company on the cusp of being THE paradigm changer in science and they highlight Sernova’s capability to  profoundly disrupt current standard of care.

For this reason Sernova Corp has to be on everyone’s radar screen. Is SVA on yours?

If not, it should be.

Richard owns shares of Sernova Corp. (TSX-V: SVA) (OTCQB: SEOVF) (FSE: PSH)

Richard lives with his family on a 160 acre ranch in northern British Columbia and is the owner of

Richard’s articles have been published on over 400 websites, including:

WallStreetJournal, USAToday, NationalPost, Lewrockwell, MontrealGazette, VancouverSun, CBSnews, HuffingtonPost, Beforeitsnews, Londonthenews, Wealthwire, CalgaryHerald, Forbes, Dallasnews, SGTreport, Vantagewire, Indiatimes, Ninemsn, Ibtimes, Businessweek, HongKongHerald, Moneytalks, SeekingAlpha, BusinessInsider,, and the Association of Mining Analysts.

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Legal Notice / Disclaimer

This document is not and should not be construed as an offer to sell or the solicitation of an offer to purchase or subscribe for any investment.

Richard Mills has based this document on information obtained from sources he believes to be reliable but which has not been independently verified.

Richard Mills makes no guarantee, representation or warranty and accepts no responsibility or liability as to its accuracy or completeness. Expressions of opinion are those of Richard Mills only and are subject to change without notice. Richard Mills assumes no warranty, liability or guarantee for the current relevance, correctness or completeness of any information provided within this Report and will not be held liable for the consequence of reliance upon any opinion or statement contained herein or any omission.

Furthermore, I, Richard Mills, assume no liability for any direct or indirect loss or damage or, in particular, for lost profit, which you may incur as a result of the use and existence of the information provided within this Report.


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I agree with all you say about toxic oils and cholesterol but you need to educate yourself about vaccines and fluoride. Did you know that vaccines contain toxic mercury, aluminum, formaldehyde embalming fluid and MSG neurotoxin?

Did you know that the EPA won't allow industrial waste fluoride to be dumped into our rivers but it's ok in our drinking water?

Watch this for a real wake up from neurosurgeon Dr Russell Blaylock MD. You'll finally realize there is a globalist poisoning agenda and it's also related to the suppression of cholesterol and the promotion of synthetic unhealthy oils you mention.

It's not just to promote industry profits, it's to suppress a unified awareness, opposition and potential threat to their globalist banking scams and corrupt rackets like the petrodollar.

Thanks for your advice to educate myself !
So I did, and as a result I humbly suggest that you should go directly to your local dentist and request that all your amalgams be removed.
He will of course recommend never to use toothpaste again, and further advise that you should be extremely careful not to swallow any of that poisonous tap water whilst rinsing.
You could then ask what he thinks of vaccines and that 'globalist poisoning agenda' which has somehow miraculously saved millions of humans suffering and/or dying from polio, whooping cough,measles, rubella, mumps and Hib Flu.

PS we do not drink "industrial waste fluoride "

Response to SW
You say, "Diabetes occurs because people eat and drink too much Sugar for the body to handle." This implies that we can cure diabetes by eating less and producing less glucose in the blood. I wish it was that simple.

You're right, Diabetes is a result of excessive glucose in the blood that isn't taken up in the cells and the body increases insulin to boost this glucose absorption to no avail because of insulin resistance exhibited by the cell. Boosting insulin by injection is also futile.

The problem isn't too little insulin because this insulin resistance is caused by the cells closing off uptake of energy-producing glucose because of the body's contamination by toxins in our air, water, food and medicine.

The toxins are causing this metabolic disorder called diabetes, so our bodies can't extract energy from our food and we're left with blood full of food waiting for processing.

We overeat in response to our body's trying to eliminate the toxins in search of critical 90-element nutrition. That's why Dr Joel Wallach describes obesity as a deficiency disease because the building toxic body burden (TBB) overwhelms our eliminative capacity.

Our body is desperate to acquire nutritional elements that can eliminate the toxins that are preventing glucose uptake and energy production in our currently closed-off insulin-resistant cells.

Our globalist controllers are experts at disabling our critical bodily functions and handicapping us with vaccines, fluoride, GMOs and chemtrails. As Mike Adams said, "It's all rigged" and he was referring to not just elections.

The food, air, water, medicine, science, history, courts, government, institutions and money to name a few are all controlled and rigged.

Our globalist controllers know just how to emotionally handicap, chemically dumb down and dominate every facit of our lives and the basis of their power is their poisoning agenda that the sheeple are completely oblivious to and continue displaying a blind allegiance to their globalist-controlled Establishment savior.

Because the internet is finally getting out the word that diabetes, like most diseases can be cured through complete 90-element nutrition, expensive, high tech, job-killing, Allopathic wonders like Sernova's Cell Pouch System will be made unnecessary.

According to veterinarian Dr Joel Wallach, over 900 diseases have been cured in animals through nutrition and humans are similar to animals, particularly pigs. A new nutritional paradigm is emerging in medicine that doesn't involve government-protected, globalist-controlled, Monopoly Allopathic Medicine.

Diabetes is nothing more than the body's cells closing off and reacting to toxicity introduced by the globalist's poisoning agenda using vaccines, fluoride, GMOs and chemtrails. It's part of a mind-control, depopulation and handicapping agenda designed to deceive, defraud and dominate the masses.

See Dr Joel Wallach's eye-opening videos on miraculous 90-element nutrition that reverses and detoxifies the globalist's poisoning agenda.

90 Essential Vitamins & Minerals Dr Wallach

Dr Wallach: Somebody Needs To Go To Jail

Cannot agree with your 'globalists poisoning agenda" claim re Diabetes.

Diabetes occurs because people eat and drink too much Sugar for the body to handle.
It is that simple.
I once demonstrated to group of colleagues the amount of food recommended by Diabetes Australia UK and USA that a person my age should eat according to health guidelines.
It is an horrendous amount of food based mainly on carbohydrates (albeit mostly veggies fruits grains dairy and beans, that are mostly of course sugar regardless of their GI.)
That diet is also 'low fat' and therein lies a big part of the problem because fat is satiating and therefore there is a tendency to overeat due to constantly feeling "hungry"
My practically nothing that man tampers with and puts in a wrapper, carton, tube or bottle and stay out of supermarkets.

Comment to Sam_site.
Well there is no doubt that there is toxicity if one eats junk and that has zero to do with vaccines and fluoride both of which have done nothing but good.
In saying that we wouldn't need either if we stuck to what is natural i.e. organic animals and produce of all types and led active lives.
Problem is the advice from diet dictocrats who believe that low fat, high carb diet is the ideal.
Low fat means to them, toxic vegetable oils,margarine etc ,eat lean meat, chicken and eat no " bad" cholesterol etc.
The evidence is clear... if you follow that advice most people will get diabetes no matter how much they exercise.
Two major epidemiological studies have shown that people all over the world with high cholesterol live longer than those with low cholesterol.
Personally I can verify that to some extent. Most of my rehab patients are elderly 80 years plus. 95% of them have hyper cholesterol.
They grew up on a diet of "meat and 3 veg" and apple pie with lashings of full cream.
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Sam-site. Thanks for your advice to educate myself ! So I did, and as a result I humbly suggest that you should go directly to your local dentist and request that all your amalgams be removed. He will of course recommend never to use toothpaste again, an  Read more
S W. - 8/13/2016 at 10:02 PM GMT
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